Vile and co-workers have reported a practical procedure for the on-demand preparation of synthetically useful azetidinium salts via aminolysis of epichlorohydrin under continuous flow conditions.
Using the Uniqsis FlowLab flow chemistry reactor system, the procedure is both simple and scalable affording high yields of products that can be isolated directly within 60 minutes at 80oC.
Typically higher yields are obtained in flow than in the corresponding batch process.
The Pd-mediated reduction of o-nitrostilbenes in the presence of carbon monoxide is reported to proceed regioselectively under pressurised flow-through conditions to cleanly afford indoles.
A variety of substrates are tolerated and the reaction proceeds significantly faster than in batch and produces carbon dioxide as the only stoichiometric side-product.
